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DeCS
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Descriptor English:
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Src Homology 2 Domain-Containing, Transforming Protein 1
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Descriptor Spanish:
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Proteína Transformadora 1 que Contiene Dominios de Homología 2 de Src
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Descriptor Portuguese:
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Proteína 1 de Transformação que Contém Domínio 2 de Homologia de Src
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Synonyms English:
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SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
SHC Transforming Protein 1
SHC-Transforming Protein 1
SHC1 (Src Homology 2 Domain-Containing) Protein
SHC1 Protein
ShcA Protein
Src Homology 2 Domain Containing Transforming Protein C1
Src Homology 2 Domain Containing, Transforming Protein 1
Src Homology 2 Domain-Containing-Transforming Protein C1
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Tree Number:
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D12.644.360.024.330.500
D12.776.157.057.162.500
D12.776.476.024.424.500
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Definition English:
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An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION. |
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History Note English:
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2017; use SHC SIGNALING ADAPTOR PROTEINS 2009-2016
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Allowable Qualifiers English:
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Record Number:
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56539
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Unique Identifier:
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D000071425
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Occurrence in VHL:
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Similar:
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DeCS
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